Insights in Biology and Medicine ISSN: 2639-6769

Opinion

The current situation of bioethics illustrates what has become known as “the anthropological halt”, described with great lucidity by C. S. Lewis in his book The Abolition of Man as the neglect of the “Tao”, a not very extensive body of basic axioms which enable the overall integrity of reason, both in theory and practice.

Export Citation CrossMark Publons Harvard Library HOLLIS GrowKudos Search IT Google Scholar ResearchGate Base Search OAI PMH Academic Microsoft Scilit Semantic Scholar

Abstract Read Full Article HTMLDOI: 10.29328/journal.ibm.1001013 Cite this Article

Abstract

According to literature, about 90% of death from cancer is related to metastasis. Metastatic process present many similarity to some other biological processes. Once we have examined some relevant biomedical literature, by understanding the real causes of metastasis, it would become much more possible to introduce new therapeutic strategies to delay or in some cases even to stop this kind of killer process. Breast cancer, as an example, produces metastasis to different organs, which seems to be related to the subtype. We believe that a deep understanding of the roles of breast cancer cells and their interactions with the liver microenvironment in early breast cancer metastasis could be a crucial factor for the design and development of effective BCLM breast cancer liver metastases therapeutic strategies and to better understand the general process. Let’s suppose the secondary organ or organs can be considered as incubator/s for the primary metastatic cells. What kind of consequences we can have in therapy field if there is an active regulating role in determining the location of secondary cancers?

Let’s observe the role played by liver, bone marrow, CNS central nervous system, lungs, lymphocytes and other secondary locations/organs a little bit closer or maybe from a different angle let’s suppose we try to come up with just a hypothesis. Just let’s take this as a possibility, and we take the thread to see where it takes us.

Export Citation CrossMark Publons Harvard Library HOLLIS GrowKudos Search IT Google Scholar ResearchGate Base Search OAI PMH Academic Microsoft Scilit Semantic Scholar

Abstract Read Full Article HTMLDOI: 10.29328/journal.ibm.1001012 Cite this Article

Abstract

The probiotic effects of Bacillus coagulans and Bacillus subtilis were studied on survival, growth, concentrations of basic biochemical constituents, activities of digestive enzymes, and their colony establishments in the gut of Macrobrachium rosenbergii post-larvae (PL). Eleven groups of PL (2.03±0.05 in length and 0.18±0.01g in weight), each consists of 35 individuals maintained in 25 L of ground water and fed ad libitum with five serially diluted concentrations, 10-1, 10-3, 10-5, 10-7 and 10-9 of B. coagulans, and B. subtilis incorporated diets containing 40% protein, for 45 days. Diet without incorporation of any of these probiotics was served as control. These probiotics were found to be alive in the respective feed even on day-15 after their formulations. Significant improvement in survival, nutritional indices (weight gain, specific growth rate, food conversion ratio and protein efficiency ratio), contents of basic biochemical constituents (total protein, amino acid, carbohydrate and lipid) and activities of digestive enzymes (protease, amylase and lipase) were observed (P<0.05), particularly in 10-7 concentration of B. coagulans, and B. subtilis incorporated diets fed PL when compared with control. The biochemical confirmation tests revealed that presence of Escherichia coli, Acetonobacter sp., Salmonella sp., and Pseudomonas sp., in the gut of control PL. In the gut of PL fed with B. coagulans incorporated diet, Acetonobacter sp., Salmonella sp., and Pseudomonas sp., were found to be competitively excluded, whereas, in the gut of PL fed with B. subtilis incorporated diet, Acetonobacter sp., and Salmonella sp., only were found to be excluded competitively. Actually, colonies of Bacillus sp., and Lactobacillus sp., were found to be establishment in the gut of PL fed with B. coagulans, and B. subtilis incorporated diets. Overall, these probiotics incorporated diets produced better growth and survival due to better FCR and activities of digestive enzymes, which in turn led to better nutritional profile. Therefore they are recommended as feed additives for sustainable culture of M. rosenbergii.

Export Citation CrossMark Publons Harvard Library HOLLIS GrowKudos Search IT Google Scholar ResearchGate Base Search OAI PMH Academic Microsoft Scilit Semantic Scholar

Abstract Read Full Article HTMLDOI: 10.29328/journal.ibm.1001011 Cite this Article

Abstract

Erectile dysfunction (ED) is a common disorder whose prevalence increases with age. Over time a strong correlation between erectile dysfunction and cardiovascular disease has been established as the result of the same pathophysiological process: endothelial dysfunction and atherosclerosis. Because small vessels of the penis can be affected by atherosclerotic plaque earlier than coronary arteries, carotids or femoral arteries, men often have symptoms of ED long before the signs of cardiovascular disease appear. For this reason, ED can act as a marker of early atherosclerosis that predicts the onset of cardiovascular disease at a later time.

Export Citation CrossMark Publons Harvard Library HOLLIS GrowKudos Search IT Google Scholar ResearchGate Base Search OAI PMH Academic Microsoft Scilit Semantic Scholar

Abstract Read Full Article HTMLDOI: 10.29328/journal.ibm.1001010 Cite this Article

Opinion

Nobody doubts that mathematics plays a crucial role in medical achievements. It is certain that is being mainly used in statistics and physics for biomedical problems [1]. For sure that we have already heard about how mathematics can improve the anticancer arsenal [2].Quantitative genetics have triggered a giant potential in medical care [3,4]. And mathematical algorithms, provided by artificial intelligence, continuously boost new therapeutic paradigms [5,6]. Nonetheless, one cannot ignore the ability of mathematics for analyzing ideas. One can see that when Soares dos Santos and colleagues [7] wondered what mathematics is able to say about how to optimize the performance of implantable medical devices, they wondered about the optimality of their research projects in the first place. What mathematics says about how to design “optimal” devices? It says that current devices are not able to ensure such performance. Will new or improved surgical techniques solve device failures? Mathematics also says «no». Will new or improved materials solve device failures? Mathematics says «it is possible, but it will be harder». Harder than what? Mathematics says: «Harder than instrumented active devices. Medical devices can perform optimal performances if they are active, i.e., if they are able to monitor their own state and the physiological states of the tissues surrounding the device, and if they are able to apply therapeutic actuations to such tissues so that the failure state is conducted to a without-failure state» [7-11]. And mathematics also says that this analysis can be applied to the overall implantable medical devices [7]. One cannot deny that mathematics is a powerful tool to identify what are the key challenges that must be addressed for unsolved problems in medicine. Thanks to mathematics, the universe of concepts is not apart from the clinical practice. However, medical research is being conducted by considering the paradoxicality of mathematics in medicine [1] as an assumption-the first challenge must be to question mathematics about the real accomplishments that our research projects can achieve.

Export Citation CrossMark Publons Harvard Library HOLLIS GrowKudos Search IT Google Scholar ResearchGate Base Search OAI PMH Academic Microsoft Scilit Semantic Scholar

Abstract Read Full Article HTMLDOI: 10.29328/journal.ibm.1001009 Cite this Article