Tong Ming Liu | Editor
Affilation: Genome Institute of Singapore, Singapore
• Co-Principal Investigator, Stem Cells and Regenerative Medicine, Genome Institute of Singapore, Jan 2012-. Investigating pathogenetic mechanisms underlying achondrodysplasia and osteogenesis imperfecta using patient-specific induced pluripotent stem cells (iPS cells).
• Co-Principal Investigator, In Stem Cells and Regenerative Medicine, Department of Orthopaedic Surgery, National University of Singapore, Jun 2006-Dec 2011. 1.Chondrogenic differentiation of human stem cells: characterising and defining the cellular and molecular mechanisms and the establishment of stable cellular phenotypes for cartilage regeneration. 2.Generating a high quality immortal mesenchymal stem cell line for chondrogenesis.
• Research fellow (A grade), In Stem cell and developmental biology, Department of Orthopaedic Surgery, National University of Singapore, Jan 2005-Jun 2006. Concentration: Gene expression profiling during differentiations of mesenchymal stem cells, Functional study of genes involving in differentiation of mesenchymal stem cells. Generation of high quality mesenchymal stem cells by genetic modification
• Research fellow (B grade), In Developmental genetics in fish stem cells, Department of Biological Sciences, National University of Singapore, Dec 2002-Dec 2004. Concentration: Stem cell culture and differentiation in fish, Establishment of a normal medakafish spermatogonial cell line.
• Ph.D. in Genetics, Institute of Hydrobiology, The Chinese Academy of Sciences, 1999-2002.
Research Interest
• Bone and cartilage disease modeling, drug screening and gene correction
• Directed differentiation of pluripotent stem cells toward cartilage and bone
• Direct reprogramming of human fibroblasts towards bone
• Gene therapy for cartilage regeneration and repair in regenerative medicine
• Signaling pathway of genes regulating cartilage differentiation of human mesenchymal stem cells
• Molecular basis of mesenchymal stem cells maintaining their stemness
• Stem cell biology and technique.
































