Research Article
Discrepancy in Microglia and Peripheral Monocytic Cells - A scope in the Pathophysiology of Psychiatric maladies
Jes Paul*
Published: 06/29/2018 | Volume 2 - Issue 1 | Pages: 028-032
Abstract
Broad medleys of research have recognized the microglial activation in perilous psychiatric maladies such as schizophrenia, bipolar disorder, and major depressive disorder. There is a scenario of enlivening of peripheral monocytic cells along with the microglial interactions within the body
while considering the Pathogenesis of psychiatric disorders.this review, epitomize and discuss the activation of microglia and monocytic cells in psychiatric disorders, thereby showcasing the potential association between these cell types and the Pathogenisis of the ailment , and proffer perspectives for future research on these processes.
Read Full Article HTMLDOI: 10.29328/journal.jnnd.1001011Cite this Article
References
- Theodoropoulou S, Spanakos G, Baxevanis CN, Economou M, Gritzapis AD, et al. Cytokine serum levels, autologous mixed lymphocyte reaction and surface marker analysis in never medicated and chronically medicated schizophrenic patients. Schizophr Res. 2001: 47: 13-25. Ref.: https://tinyurl.com/yc8hn2g5
- Padmos RC, Hillegers MH, Knijff EM, Vonk R, Bouvy A, et al. A discriminating messenger RNA signature for bipolar disorder formed by an aberrant expression of inflammatory genes in monocytes. Arch Gen Psychiatry. 2008; 65: 395-407. Ref.: https://tinyurl.com/ycuy8zew
- Drexhage RC, Hoogenboezem TH, Versnel MA, Berghout A, Nolen WA, et al. The activation of monocyte and T cell networks in patients with bipolar disorder. Brain Behav Immun. 2011; 25: 1206-1213. Ref.: https://tinyurl.com/yc8kq6zp
- Beumer W, Gibney SM, Drexhage RC, Pont-Lezica L, Doorduin J, et al. The immune theory of psychiatric diseases: a key role for activated microglia and circulating monocytes. J Leukoc Biol. 2012; 92: 959-975. Ref.: https://tinyurl.com/ybb4oux3
- Shechter R, Schwartz M. Harnessing monocyte-derived macrophages to control central nervous system pathologies: no longer ’if’ but ’how’. J Pathol. 2013; 229: 332-346. Ref.: https://tinyurl.com/y7lzabtj
- Prinz M, Priller J. Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease. Nat Rev Neurosci. 2014; 15: 300-312. Ref.: https://tinyurl.com/ybkufv35
- Schmitz G, Leuthäuser-Jaschinski K, Orsó E. Are circulating monocytes as microglia orthologues appropriate biomarker targets for neuronal diseases? Cent Nerv Syst Agents Med Chem. 2009; 9: 307-330. Ref.: https://tinyurl.com/y7xnsauh
- Radewicz K, Garey LJ, Gentleman SM, Reynolds R. Increase in HLA-DR immunoreactive microglia in frontal and temporal cortex of chronic schizophrenics. J Neuropathol Exp Neurol. 2000; 59: 137-150. Ref.: https://tinyurl.com/y8y2m558
- Tang B, Capitao C, Dean B, Thomas EA. Differential age- and disease-related effects on the expression of genes related to the arachidonic acid signaling pathway in schizophrenia. Psychiatry Res. 2012; 196: 201-206. Ref.: https://tinyurl.com/yd9ebusa
- Fillman SG, Cloonan N, Catts VS, Miller LC, Wong J, et al. Increased inflammatory markers identified in the dorsolateral prefrontal cortex of individuals with schizophrenia. Mol Psychiatry. 2013; 18: 206-214. Ref.: https://tinyurl.com/y7vvjpv3
- Hercher C, Chopra V, Beasley CL. Evidence for morphological alterations in prefrontal white matter glia in schizophrenia and bipolar disorder. J Psychiatry Neurosci. 2014; 39: 376-385. Ref.: https://tinyurl.com/yckzl89r
- Torres-Platas SG, Cruceanu C, Chen GG, Turecki G, Mechawar N. Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides. Brain Behav Immun. 2014; 42: 50-59. Ref.: https://tinyurl.com/yaqhkzae
- Ginhoux F, Greter M, Leboeuf M, Nandi S, See P, et al. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science. 2010; 330: 841-845. Ref.: https://tinyurl.com/ycq4wtnl
- Schulz C, Gomez Perdiguero E, Chorro L, Szabo-Rogers H, Cagnard N, et al. A lineage of myeloid cells independent of Myb and hematopoietic stem cells. Science. 2012; 336: 86-90. Ref.: https://tinyurl.com/ycwl9vmk
- Kierdorf K, Erny D, Goldmann T, Sander V, Schulz C, et al. Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways. Nat Neurosci. 2013; 16: 273-280. Ref.: https://tinyurl.com/yaarr2ta
- Goldmann T, Wieghofer P, Muller PF, Wolf Y, Varol D, et al. A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation. Nat Neurosci. 2013; 16: 1618-1626. Ref.: https://tinyurl.com/y8d2xeom
- Parkhurst CN, Yang G, Ninan I, Savas JN, Yates JR, et al. Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell. 2013; 155: 1596-1609. Ref.: https://tinyurl.com/y982squc
- Yona S, Kim KW, Wolf Y, Mildner A, Varol D, et al. Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis. Immunity. 2013; 38: 79-91. Ref.: https://tinyurl.com/ya69vcpm
- Barger SW, Basile AS. Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function. J Neurochem. 2001; 76: 846-854. Ref.: https://tinyurl.com/yb2fk4yu
- Takaki J, Fujimori K, Miura M, Suzuki T, Sekino Y, et al. L-glutamate released from activated microglia downregulates astrocytic L-glutamate transporter expression in neuroinflammation: the ‘collusion’hypothesis for increased extracellular L-glutamate concentration in neuroinflammation. J Neuroinflammation. 2012; 9: 275. Ref.: https://tinyurl.com/ycljbm2s
- Réus GZ, Fries GR, Stertz L, Badawy M, Passos IC, et al. The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders. Neuroscience. 2015; 300: 141-154. Ref.: https://tinyurl.com/yakqh2dr
- Schmitz G, Grandl M. Role of redox regulation and lipid rafts in macrophages during Ox-LDL-mediated foam cell formation. Antioxid Redox Signal. 2007; 9: 1499-1518. Ref.: https://tinyurl.com/y9vf3foz
- Gordon S, Taylor PR. Monocyte and macrophage heterogeneity. Nat Rev Immunol. 2005; 5: 953-964. Ref.: https://tinyurl.com/y9eelb4a
- Lutter D, Ugocsai P, Grandl M, Orso E, Theis F, et al. Analyzing M-CSF dependent monocyte/macrophage differentiation: expression modes and meta-modes derived from an independent component analysis. BMC Bioinformatics. 2008; 9: 100. Ref.: https://tinyurl.com/ydbsblcj
- Simard AR, Soulet D, Gowing G, Julien JP, Rivest S. Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer’s disease. Neuron. 2006; 49: 489-502. Ref.: https://tinyurl.com/ybr2rxb5
- Mildner A, Schlevogt B, Kierdorf K, Böttcher C, Erny D, et al. Distinct and non-redundant roles of microglia and myeloid subsets in mouse models of Alzheimer’s disease. J Neurosci. 2011; 31: 11159-11171. Ref.: https://tinyurl.com/y9sggxqk
- Banks WA, Erickson MA. The blood-brain barrier and immune function and dysfunction. Neurobiol Dis. 2010; 37: 26-32. Ref.: https://tinyurl.com/ya68yfzp
- Spiegel A, Kalinkovich A, Shivtiel S, Kollet O, Lapidot T. Stem cell regulation via dynamic interactions of the nervous and immune systems with the microenvironment. Cell Stem Cell. 2008; 3: 484-492. Ref.: https://tinyurl.com/y8y7vabf
- Jes Paul , Paulose CS, John PS, Sreekanth R, Mathew Philip, et al. Spinal Cord Regeneration and Functional Recovery: Neurotransmitter’s Combination and Bone Marrow Cells Supplementation. J Current Sci. 2009; 25: 546-549.














