Research Article
Brain changes in Hypothermia: Surface-versus Core-cooling in pigs
Hammersborg SM, Husby P, Morild I, and Lilleng PK
Published: 10/31/2017 | Volume 1 - Issue 2 | Pages: 092-097
Abstract
The process of hypothermia in the clinical setting has been practiced for 50 years and is known for its neuroprotective properties. This paper describes histopathological changes either by an ice sludge mimicking accidental hypothermia (S-group n=7) or by endovascular core-cooling (C-group n=7). Focal infiltrates of neutrophilic granulocytes were found in five of seven brains in the S-group and in one of seven brains in the C-group. These granulocytes were found in the arachnoids, in vessels, in vessel walls, and in the cerebral cortex. Fungi, bacteria, lymphocytes or plasma were not found.
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