Lingyan Wang | Editor
Affilation: Oregon Heath & Science University, USA
Since 1999, I have been working in the fields of Animal Histology and Embryology. Before 2006, my research emphasis had been on the study of animal histological/ultrastructure analysis. From 2006 to 2009, my research works mainly focus on animal embryonic biotechnology, such as nuclear transfer/animal cloning (in pigs and golden hamsters), animal transgenics (in mice and goats), in vitro fertilization (in cattle and golden hamsters) etc. I am proficient in micromanipulation (microsurgery) and histological/ultrastructure analysis. I have the knowledge and experience of clinical works and animal husbandry also.
In 2009, I came to the Oregon Health and Science University, USA, and joined in Dr. Brigande Lab as a postdoctoral researcher. My project is to study inner ear development in late embryonic stage and restore hearing in transgenic mouse mutant using unique trans-uterus injection techniques for gene therapy. There is a critical need for an improved animal model for investigations of human inherited hearing loss disease and to test gene therapy approaches. In March 2014, my position title has been promoted to Research Associate.
Research Interest
My main interests are in veterinary medicine and development biology. I mainly worked on histological changes of Laiwu Black Goat’s pineal gland through the season for my Master’s degree. This study helps us to understand the relationship between pineal gland and reproductive ability. I mainly worked on hamster early embryo development (from zygote to blastocyst) for my PhD, including oocytes spontaneous parthenogenetic activation, reciprocal position of the first polar body, ageing and anti-ageing of golden hamster oocytes, assisting enucleation of hamster oocytes, somatic cell nuclear transfer and hamster cloning. My current project is mammalian inner ear development in late embryonic stage. The research interests are fate of otic epithelial progenitors in the mouse otic vesicle, lineage relationships of sensory and nonsensory cells in the mouse inner ear and molecular regulation of sensory organ formation. I use the unique in utero gene transfer technique to study gene gain and loss of function in the developing mouse inner ear, which is the prerequisite of fetal gene therapy in human.
