Research Article
Nano-formulations for Ophthalmic Treatments
Mahima John and Rajesh N Gacche*
Published: 12/29/2017 | Volume 1 - Issue 1 | Pages: 028-035
Abstract
Ocular disorders encompass a multitude of diseases that are unique in their cause, therapy and degree of severity. Due to distinctive morphology of the eye, efficient ocular drug delivery has proven to be a difficult task. Current treatments of ophthalmological diseases include the usage of both intrusive as well as nonintrusive methods such as injections, eye drops, ointments, gels etc. The current state of the art drug delivery methods are associated with low bioavailability and therefore nanotechnology based drug delivery approached are evolving as for improving the therapeutic index of currently used drugs against variety of ocular disorders. This review highlights the recent developments in nano-formulations for ophthalmic treatment and also offers discussions towards the future prospectus of nano-formulations in the mainstream of ophthalmic diseases.
Read Full Article HTMLDOI: 10.29328/journal.hps.1001005Cite this Article
References
- Ann-Marie Ako-Adounvo, Ramesh C Nagarwal, Lais Oliveira, Sai H.S. Boddu, Xiang S Wang, et al. Recent patents on ophthalmic nanoformulations and therapeutic implications. Recent Pat Drug Deliv Formul. 2014; 8: 193-201. Ref.: https://goo.gl/cnNA1Y
- Carroll J, Neitz M, Hofer H, Neitz J, Williams DR. Functional photoreceptor loss revealed with adaptive optics: An alternate cause of color blindness. Proc Natl Acad Sci U S A. 2004; 101: 8461-8466. Ref.: https://goo.gl/Cm9RXU
- C.P Wilkinson, Frederick L Ferris, Ronald E Klein, Paul P Lee, et al. Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology J. 2003; 110: 1677-1682. Ref.: https://goo.gl/Ft5L3J
- Dyonne T Hartong, Eliot, L Berson, Thaddeus PD. Retinitis pigmentosa. The Lancet. 2006; 368: 18-24. Ref.: https://goo.gl/ErW6Yg
- Kenneth P Cheng, David A Hiles, Albert W Biglan, Milton C Pettapiece. Visual Results after Early Surgical Treatment of Unilateral Conenital Cataracts. Ophthalmology J. 1991; 98: 903-910. Ref.: https://goo.gl/X6RKJF
- SibelCetinel, Carlo Montemagno. Nanotechnology for the Prevention and Treatment of Cataract. Asia-Pacific J Ophthalmology. 2015; 4: 381-387. Ref.: https://goo.gl/74QdCK
- Jonathan L Haines, Michael A Hauser, Silke Schmidt, William K Scott, Lana M Olson, et al. Complement Factor H Variant Increases the Risk of Age-Related Macular Degeneration. Science Journal. 2005; 308: 419-421. Ref.: https://goo.gl/boQqiH
- Paul J Foster, Ralf Buhrmann, Harry A Quigley, Gordon J Johnson. The definition and classification of glaucoma in prevalence surveys. British J Opthamology. 2002; 86: 238-242. Ref.: https://goo.gl/HPTjnG
- Maurice DM, Mishima. Handbook of Experimental Pharmacology. In Ocular pharmacokinetics. 1989; 57: 16-119.
- Hong-Yang Zhou, Ji-Long Hao, Shuang Wang, Yu Zheng, Wen-Song Zhang. Nanoparticles in the ocular drug delivery. Int J Ophthalmol. 2013; 6: 390-396. Ref.: https://goo.gl/LatWrz
- Xiaoyong Yuan, Daniela C Marcano, Crystal S Shin, Xia Hua, Lucas C Isenhart, et al. Ocular Drug Delivery Nanowafer with Enhanced Therapeutic Efficacy. J American Chemical Society. 2015; 9: 1749-1758. Ref.: https://goo.gl/XUtyUL
- Bhatia S, Saurabh A. Natural Polymer Drug Delivery Systems. Springer International Publishing Switzerland. Natural Polymer Drug Delivery Systems. 2016; 1: 33-46.
- Noriaki Nagai, Yoshimasa Ito. A New Preparation Method for Ophthalmic Drug Nanoparticles. Pharm Anal Acta. 2014; 5: 305. Ref.: https://goo.gl/eLQZH7
- Shyam S Chaurasia, Rayne R Lim, Rajamani Lakshminarayanan, Rajiv R Mohan. Nanomedicine Approaches for Corneal Diseases. J Funct Biomater. 2015; 6: 277-298. Ref.: https://goo.gl/o7vjZs
- Yuhua Weng, Juan Liu, Shubin Jin, Weisheng Guo, Xingjie Liang et al. Nanotechnology-based strategies for treatment of Ocular disease. Acta Pharm Sin B. 2017; 7; 281-291. Ref.: https://goo.gl/xZzpFG
- Luu CD, Lau AM, Koh AH, Tan D. Multifocal electroretinogram in children on atropine treatment for myopia. British J Ophthalmol. 2005; 89: 151-153. Ref.: https://goo.gl/AMckhK
- Marzieh Fathi, Jaleh Barar, Ayuob Aghanejad, Yadollah Omidi. Hydrogels for ocular drug delivery and tissue engineering. Bioimpacts. 2015; 5: 159-164. Ref.: https://goo.gl/PZLm1j
- Vishal R Patel, Agrawal YK. Nanosuspension: An approach to enhance solubility of drugs. J Advanced Pharmaceutical Technology & Research. 2011; 2: 81-87. Ref.: https://goo.gl/hk6GWE
- Gyan P Mishra, Mahuya Bagui, Viral Tamboli, Ashim K Mitra. Recent Applications of Liposomes in Ophthalmic Drug Delivery. J Drug Delivery. 2011; 2011: 1-14. Ref.: https://goo.gl/P5EoBM
- Abhirup Mandal, Rohit Bisht, Ilva D Rupenthal, Ashim K Mitra. Polymeric micelles for ocular drug delivery: From structural frameworks to recent preclinical studies. J Controlled Release. 2017; 248: 96-116. Ref.: https://goo.gl/wXFVx4
- Ammar HO, Salama HA, Ghorab, Mahmoud. Nanoemulsion as a potential ophthalmic delivery system for dorzolamide hydrochloride. AAPS PharmSciTech. 2009; 10: 808-819. Ref.: https://goo.gl/Thnc6H
- Frederic Lallemand, Philippe Daull, Simon Benita, Ronald Buggage, Jean-Sebastien Garrigue. Successfully Improving Ocular Drug Delivery Using the Cationic Nanoemulsion, Novasorb. J Drug Delivery. 2012; 1-16. Ref.: https://goo.gl/A1kSiu
- Luigi Battaglia, Loredana Serpe, Federica Foglietta, Elisabetta Muntoni, Marina Gallarate, et al. Application of lipid nanoparticles to ocular drug delivery. Expert Opin Drug Deliv. 2016; 13: 1743-1757. Ref.: https://goo.gl/zYfRj1
- Marina Kalomiraki, Kyriaki Thermos, Nikos A Chaniotakis. Dendrimers as tunable vectors of drug delivery systems and biomedical and ocular applications. Int J Nanomedicine. 2016; 11: 1-12. Ref.: https://goo.gl/YC8TYi
- Harry A Quigley. Nanotechnology-based strategies for treatment of ocular disease. British J Opthamology. 1996; 7: 238-242.
- Yuan X, Marcano DC, Shin CS, Hua X, Isenhart LC, et al. Ocular drug delivery nanowafer with enhanced therapeutic efficacy. ACS Nano. 2015; 9: 1749-1758. Ref.: https://goo.gl/H4afK3
- Jiang M, Gan L, Zhu C, Dong Y, Liu J, et al. Cationic core shell lipo nanoparticles for ocular gene delivery. Biomaterials. 2012; 33: 7621-7630. Ref.: https://goo.gl/AYyRLF
- Shuai Shi, Zhaoliang Zhang, Zichao Luo, Jing Yu, Renlong Liang, et al. Chitosan grafted methoxy poly(ethylene glycol)-poly(ε-caprolactone) nanosuspension for ocular delivery of hydrophobic diclofenac. Sci Rep. 2015; 5: 11337. Ref.: https://goo.gl/3oZfgN
- Panagiotis Mastorakos, Siva P Kambhampati, Manoj K Mishra, Tony Wu, Eric Song, et al. Hydroxyl PAMAM dendrimer-based gene vectors for transgene delivery to human retinal pigment epithelial cells. Nanoscale. 2015; 7: 3845-3856. Ref.: https://goo.gl/N7Aqkg
- Colin J. Ganciclovir ophthalmic gel, 0.15%: a valuable tool for treating ocular herpes. Clin Ophthalmol. 2007; 1: 441-453. Ref.: https://goo.gl/2pkGU5
- Lin HR, Sung KC. Ophthalmic drug delivery formulations and method for preparing the same. 2003.














