Research Article
Role of Carcinoma Associated Fibroblasts in Anoikis Resistance in Oral Squamous Cell Carcinoma –need of the hour
Anjali Ganjre*
Published: 01/30/2017 | Volume 1 - Issue 1 | Pages: 001-004
SUMMARY
Anoikis resistance (AR) is a favorable attribute exhibited by cancer cells for metastasis. Carcinoma associated Fibroblasts (CAFs) plays a crucial role in AR in various cancers. It was proved in array of studies in different cancers that there was definite interrelationship between CAFs and AR. But its role in OSCC is ambiguous. It is the need of the time to reveal the correlation of CAF and oral squamous cell carcinoma (OSCC) in relation with anoikis. Molecular pathways which affects the AR via CAFs in various cancers has been highlighted in this communication. Divulging the importance of CAF in cancer will aid in designing customized novel chemoprevention therapy and thus will help in enhancing the prognosis of patient in OSCC.
Read Full Article HTMLDOI: 10.29328/journal.hjpcr.1001001Cite this Article
REFERENCES
- Kim YN, Koo KH, Sung JY, Yun UJ, Kim H. Anoikis Resistance: An Essential Prerequisite for Tumor Metastasis. International Journal of Cell Biology. 2012; 11. Ref.: https://goo.gl/WdRz6A
- Martinez-Outschoorn UE, Balliet RM, Rivadeneira DB, Chiavarina B, Pavlides S, et al. Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells. Cell Cycle. 2010; 9: 3256-3276. Ref.: https://goo.gl/NmYRJU
- Taguchi A, Kawana K, Tomio K, Yamashita A, Isobe Y, et al. Matrix Metalloproteinase (MMP)-9 in Cancer-Associated Fibroblasts (CAFs) Is Suppressed by Omega-3 Polyunsaturated Fatty Acids in vitro and in vivo. PLoS One. 2014; 9: e89605 Ref.: https://goo.gl/W6iy5l
- Weigel KJ, Jakimenko A, Conti BA, Chapman SE, Kaliney WJ, et al. CAF-Secreted IGFBPs Regulate Breast Cancer Cell Anoikis. Mol Cancer Res. 2014; 12: 855-866. Ref.: https://goo.gl/sBjtCq
- Bunek J, Kamarajan P, Kapila YL. Anoikis Mediators in Oral Squamous Cell Carcinoma. Oral Dis. 2011; 17: 355-361. Ref.: https://goo.gl/LDcTTN
- Yu Y, Xiao CH, Tan LD, Wang QS, Li XQ, et al. Cancer-associated fibroblasts induce epithelial–mesenchymal transition of breast cancer cells through paracrine TGF- β signaling. Br J Cancer. 2014; 110: 724-732. Ref.: https://goo.gl/VltEyD
- Nagafuchi A, Shirayoshi Y, Okazaki K, Yasuda K, Takeichi M. Transformation of cell adhesion properties by exogenously introduced E-cadherin cDNA. Nature. 1987; 329: 341-343. Ref.:https://goo.gl/RLBPnQ
- Li G, Satyamoorthy K, Herlyn M. N-cadherin-mediated intercellular interactions promote survival and migration of melanoma cells. Cancer Research. 2001; 61: 3819-3825. Ref.: https://goo.gl/5KBDwo
- Pavlides S, Vera I, Gandara R, Sneddon S, Pestell RG, et al. Warburg Meets Autophagy: Cancer-Associated Fibroblasts Accelerate Tumor Growth and Metastasis via Oxidative Stress, Mitophagy, and Aerobic Glycolysis. Antioxid. Redox Signal. 2012; 16: 1264-1284. Ref.: https://goo.gl/1aqEaa
- Shirakihara T, Horiguchi K, Miyazawa K, Ehata S, Shibata T, et al. TGF- β regulates isoform switching of FGF receptors and epithelial–mesenchymal transition. The EMBO J. 2011; 30: 783-795. Ref.: https://goo.gl/MQW8uB
- Giannoni E, Bianchini F, Calorini L, Chiarugi P. Cancer associated fibroblasts exploit reactive oxygen species through a proinflammatory signature leading to epithelial mesenchymal transition and stemness. Antioxid Redox Signal. 2011; 14: 2361-2371. Ref.: https://goo.gl/SbJcZp
- Paoli P, Giannoni E, Chiarugi P. Anoikis molecular pathways and its role in cancer progression. Biochim Biophys Acta. 2013; 1833: 3481-3498. Ref.: https://goo.gl/nwMakG
- Smith BN, Bhowmick NA. Role of EMT in Metastasis and Therapy Resistance. J Clin Med. 2016; 5: 17. Ref.: https://goo.gl/eaZ96n
- Muñoz NM, Baek JY, Grady WM. TGF-β has paradoxical and context dependent effects on proliferation and anoikis in human colorectal cancer cell lines. Growth Factors. 2008; 26: 254-262. Ref.: https://goo.gl/iYuwMJ
- Horowitz JC, Lee DY, Waghray M, Keshamouni VG, Thomas PE, et al. Activation of the Pro-survival Phosphatidylinositol 3-Kinase/AKT Pathway by Transforming Growth Factor1 in mesenchymal cells is mediated by p38 MAPK-dependent induction of an autocrine growth factor. The journal of biological chemistry. 2004; 279: 1359-1367. Ref.: https://goo.gl/m20lI8
- Diamond ME, Sun L, Ottaviano AJ, Joseph MJ, Munshi HG. Differential growth factor regulation of N-cadherin expression and motility in normal and malignant oral epithelium. J Cell Sci. 2008; 121: 2197-2207. Ref.: https://goo.gl/uhYHs6
- Kim BG, Gao MQ, Choi YP, Kang S, Park HR, et al. Invasive breast cancer induces laminin-332 upregulation and integrin β4 neoexpression in myofibroblasts to confer an anoikis-resistant phenotype during tissue remodeling. Breast Cancer Research. 2012; 14: R88. Ref.: https://goo.gl/K0O1Jo














