Research Article

The alterations effects in phosphorus of erythropoietin and U-74389G

C Τsompos, C Panoulis, A Triantafyllou, CG Zografos, K Tsarea, M Karamperi and A Papalois

Published: 04/13/2020 | Volume 3 – Issue 1 | Pages: 021-026

Abstract

Aim: This study calculated the effects on serum phosphorus (P) levels, after treatment with either of 2 drugs: the erythropoietin (Epo) and the antioxidant lazaroid (L) drug U-74389G. The calculation was based on the results of 2 preliminary studies, each one of which estimated the certain influence, after the respective drug usage in an induced ischemia reperfusion (IR) animal experiment.

Materials and methods: The 2 main experimental endpoints at which the serum P levels were evaluated was the 60th reperfusion min (for the groups A, C and E) and the 120th reperfusion min (for the groups B, D and F). Specially, the groups A and B were processed without drugs, the groups C and D after Epo administration; whereas the groups E and F after the L administration.

Results: The first preliminary study of Epo presented a non significant hyperphosphoremic effect by 2.46% + 2.02% (p – value = 0.2168). However, the second preliminary study of U-74389G presented a non significant hypophosphoremic effect by 1.09% + 2.01% (p – value = 0.5771). These 2 studies were co-evaluated since they came from the same experimental setting. The outcome of the co-evaluation was that L is at least 0.4455128-fold [0.4445589 – 0.4464687] more hypophosphoremic than Epo (p – value = 0.0000).

Conclusion: The anti-oxidant capacities of U-74389G ascribe at least 0.4455128-fold [0.4445589 – 0.4464687] more effects than Epo (p – value = 0.0000).

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