July 2017

Does serum uric acid play a protective role against tissue damage in cardiovascular and metabolic diseases?

Alexander E Berezin*

Abstract

Previous clinical, observation and epidemiologic studies have demonstrated strong association between serum uric acid (SUA) and cardiovascular disease (hypertension, heart failure, and asymptomatic atherosclerosis), metabolic states (abdominal obesity, diabetes mellitus, meta...

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Changes in the frequency and intensity of Tinnitus using the Suppressive Noise Spectrum

Ming Zhang*, Alysia Jeske and Sarah Young

ABSTRACT

Objective: To report findings of improvement in patient tinnitus intensity and changes in frequency using a novel suppressive noise spectrum.

Design: Single-subject; each subject served as his or her own control. Each patient receiv...

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Behavioral factors of Abdominal Obesity and effects of lifestyle changes with Fiber Adequacy

Roberto Carlos Burini*, Hugo Tadashi Kano, Mariana Santoro Nakagaki, Patricia Baston Frenhani and Katia Cristina Portero-McLellan

ABSTRACT

The etiology of abdominal obesity is multifactorial and has environmental factors as its most expressive risk factors. This study cross-sectional analyzed the association of abdominal fatness with physical inactivity and food inadequacy of 1,557 subjects, both genders, over 3...

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Low Level Light Therapy (LLLT): Penetration and Photobiomodulation

Cecilia Young* and Cheuk Lam Mak

Editorial

Mester et al. stated the laser effects in a review of their studies of 15 various biological systems, they observed the stimulating effect of low energy (in terms of J/cm2) laser and inhibiting effect of high energy laser and later reported the relationship of cumulative ene...

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Enamel demineralization with resin modified gic and conventional composite resin - a comparative in vivo study

Gautam G*, Shashikala Kumari V Garima Garg and Vikram Shetty

ABSTRACT

Background & Objectives: Fluoride releasing bonding agents can help the orthodontist to minimize enamel demineralization independent of patient cooperation. This in vivo  study was conducted to evaluate the efficacy of resin modifi ed glass ionomer c...

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Yaws essentials: What health professionals should know about yaws

Pirabu Diego-Abelardo Alvarez-Hernandez* and Alexia S Rivera

Editorial

Yaws is recognized by the World Health Organization (WHO) as 1 of the 20 Neglected Tropical Diseases (NTDs), a group of communicable diseases that have subsisted in tropical and subtropical environments, and that affect people living in poor and marginalized societies [1].Ya...

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Transglutaminase inhibition: possible therapeutic mechanisms to protect cells from death in neurological disorders

Rosaria Romano, Nicola Gaetano Gatta, Elenamaria Fioretti and Vittorio Gentile*

ABSTRACT

Transglutaminases are a family of Ca2+-dependent enzymes which catalyze post-translational modifications of proteins. The main activity of these enzymes is the cross-linking of glutaminyl residues of a protein/peptide substrate to lysyl residues of a protein/peptide co-substr...

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Enhancing adipose stem cell chondrogenesis: A study on the roles of dexamethasone, transforming growth factor β3 and ascorbate supplements and their combination

Arshan Nazempour##, Chrystal R Quisenberry##, Nehal I Abu-Lail and Bernard J Van Wie*

Abstract

Varied exogenous chondrogenic factors (CFs) are implicated in promoting differentiation of stem cells along a chondrocyte lineage in the field of regenerative tissue engineering for articular cartilage repair. The effects of dexamethasone, transforming growth factor β3 (...

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Surgical Implantation of Stem Cells in Heart Failure Patients due to Idiophatic Cardiomyopathy

Benetti Federico*, Natalia Scialacomo, Enrique Mariani, Luis Geffner, Bruno Benetti Eng, Daniel Brusich, Yan Duarte and Ernesto Penaherrera

Abstract

Introduction: Congestive heart failure is one of the main causes of morbidity and mortality in the XXI century given the promising to date of ABMDSCs and HFDSCs we investigate the safety and efficacy for the implantation of those stem cells for the treatment ...

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The advances and challenges of Gene Therapy for Duchenne Muscular Dystrophy

Jean-Paul Iyombe-Engembe and Jacques P Tremblay*

ABSTRACT

Since the discovery of the dystrophin gene (DMD gene) thirty years ago, several therapeutic approaches have been investigated to treat Duchenne muscular dystrophy (DMD). This includes cell therapy, exon jumping, exonic knockout, and the CinDel method. In this article, we pres...

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Progress in the development of Lipoplex and Polyplex modifi ed with Anionic Polymer for effi cient Gene Delivery

Yoshiyuki Hattori*

ABSTRACT

Nucleic acid-based therapy has become an increasingly important strategy for treating a variety of human diseases. In systemic therapy, a therapeutic gene must be delivered efficiently to its target tissues without side effects. To deliver a therapeutic gene such as plasmid D...

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Paediatric Medicines: Formulation Considerations

Fatima Roque*

Abstract

The use of unlicensed and off-label medicines in children is widespread and has raised an increasing concern over the last years. The majority of medicines taken by children are extemporaneously compounded by pharmacist, and there is a lack of information regarding bioavailab...

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Sense and antisense Oligodeoxynucleotides to Glun1 Nmdar are Cognitive Enhancers (Nootropics) and protective agents in normal and ischemic (Anoxic) conditions-In vitro study

Anatoly A Mokrushin*

Abstract

Aims: Implication of modified N-methyl-D-aspartate receptors (NMDAR) in synaptic plasticity and learning was investigated in normal and pathological conditions.

Study design: We studied the efficiency of synaptic plasticity, the dev...

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Radiological evaluation of a Chondromyxoid Fibroma

Austin Fletcher* and Megan Mastragostino

ABSTRACT

Chondromyxoid fibroma (CMF) is a very rare benign cartilaginous tumor representing less than 0.5% of all bone tumors while also being the rarest cartilaginous bone tumor. Common locations of occurrence include the metaphysial region of the proximal tibia and distal femur. We ...

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Anemia due to a rare anomaly - Case Report

S Nanthakumar*, Sumathi Bavanandam, Nirmala Dheivamani, Natarajan B and Krishna Mohan

ABSTACT

Anemia due to gastrointestinal blood loss can occur due to many conditions and rarely to bowel structural anomalies. We report a 12 years old girl with anemia due to small bowel duplication cyst, posing diagnostic challenge intra operatively. Surgery offered cure without recur...

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Characterisation of Delayed Onset of Muscle Soreness (DOMS) in the hand, wrist and forearm using a finger dynamometer: A pilot study

Gareth Jones*, Kristina Grancharska and Mark I Johnson

Abstract

Background: Experimentally-induced delayed-onset muscle soreness of large muscle groups is frequently used in as an injurious model of muscle pain. We wanted to develop an experimental model of DOMS to to mimic overuse injuries from sports where repeated fing...

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First Metatarsal Stress Fracture of a pre-adolescent female Irish dancer with Medial Plantar Foot Pain: A Case Report

Dale Gerke and Jean-Michel Brismee*

ABSTRACT

Background and Purpose: Injuries for the pre-adolescent female Irish Dancer (FID) are not well recognized. The purpose of this case study is to report imaging assisted diagnosis and management of atypical medial and plantar foot pain (MPFP) in an 8-year-old F...

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A great mimicker of Bone Secondaries: Brown Tumors, presenting with a Degenerative Lumber Disc like pain

Zuhal Bayramoglu*, Ravza Yılmaz and Aysel Bayram

ABSTRACT

This report presents an adult patient suffering from sacroiliitis like low back pain, lumbosacral radiculopathy and elbow swelling. Multimodality imaging revealed multiple lytic bone lesions located in supra acetabular iliac bone, sacrum, and distal end of radius. Painful num...

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Trichomonas Vaginalis-A Clinical Image

Astrit M Gashi*

Case Report

A 32-year-old G4P301LC3 woman presents to the office for a visit, with a 6-day history of vaginal discharge with an unpleasant odor. On speculum examination, the discharge was green in color and frothy in appearance. Is noticed vulvar erythema, edema, and pruritus, also is...

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A rare Congenital Coronary Artery Anomaly: Woven Right Coronary Artery associated with Myocardial Infarction

Tolga Dogan, Mucahit Yetim, Lutfu Bekar, Oguzhan Celik, Macit Kalcık* and Yusuf Karavelioglu

CASE PRESENTATION

Woven coronary artery (WCA) is an extremely rare and still not a clearly defined coronary anomaly. It is characterized by the division of epicardial coronary artery into thin channels which then reanastomose with the distal part of the abnormal coronary artery [1].&n...;

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Investigation of Retinal Microvascular Findings in patients with Coronary Artery Disease

Tolga Dogan*, Osman Akın Serdar, Naile Bolca Topal and Ozgur Yalcınbayır

ABSTRACT

Objectives: Retinal microvascular anomalies may be a marker for cardiovascular diseases. Our aim in this study was to investigate the utility of ocular fundoscopic examination as a noninvasive method in specifying the patients who carry a risk for coronary ar...

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Is advanced Coupling Methods best fitted in Biosensing of Microparticles?

Alexander E Berezin*

Microparticles (MPs) are considered important diagnostic biological markers in many diseases with promising predictive value. There are several methods that currently used for the detection of number and characterization of structure and features of MPs. Therefore, the MP detection methods hav...

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Systolic Blood Pressure Determinants

Rabindra Nath Das*

Abstract

Hypertension and blood pressure are closely related, and hypertension is directly related with stroke. There are different type of blood pressures such as basal, diastolic, maximum, mean arterial, systolic, mean central venous. The present report examines the determinants of ...

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Pure Erythroid Leukemia: The Sole Acute Erythroid Leukemia

Fauzia Shafi Khan*, Khalid Mahmood and Alia Ahmad

ABSTRACT

Pure Erythroid Leukemia (PEL) is an aggressive and exceedingly rare form of acute leukemia. In the 2008 WHO classification PEL was one of the subtypes of acute erythroid leukemia the other subtype being erythroleukemia (erythroid/ myeloid). In the 2016 WHO classification upda...

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Knowledge, attitude and practices associated with diagnosis and management of Skin and Soft Tissue Infections (SSTIs) among Pediatric Residents and Physicians in a Tertiary Hospital in United Arab Emirates (UAE)

Eiman Al Blooshi, Farah Othman, Abeer Al Naqbi, Majid Al Rumaithi, Khawla Fikry, Mariam Al Jneibi and Hossam Al Tatari*

SUMMARY

Objectives: The study aims to assess the knowledge, attitude and practices of physicians who deal with pediatric age group SSTIs in reference to the Infectious Diseases Society of America (IDSA) guidelines on this regard that was published in 2014.

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A rare cause of obstructive jaundice-case report

Priya Mohan*, Sumathi Bavanandam and Sunil Kumar KS

ABSTRACT

Obstructive jaundice in children is not uncommon and has diverse etiologies. We report a rare cause of obstructive jaundice, cholangitis and pancreatic mass in a young boy due to eosinophilic cholangiopathy who responded to oral steroids. Presence of peripheral eosinophilia, ...

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Factors affecting muscle strength in cancer patients receiving chemotherapy

Jiro Nakano*, Shun Ishii, Takuya Fukushima, Ayumi Natsuzako, Junya Sakamoto and Minoru Okita

ABSTRACT

This study aimed to investigate the relationship between muscle weakness and cancerrelated symptoms in patients undergoing chemotherapy for hematological malignancies and solid tumors. We recruited hospitalized patients older than 20 years who were receiving chemotherapy. Pat...

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The effects of early low dose exposures to the Environmental Estrogen Bisphenol A on the Development of Childhood Asthma

Terumi Midoro-Horiuti* and Randall M Goldblum

SUMMARY

Exposure to environmental chemicals is a potential cause for the rapid increase in the prevalence of allergic asthma over the last few decades. The production of the environmental estrogen bisphenol A, the monomer of polycarbonate plastics, has increased rapidly over the last ...

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