2021-10-15T20:22:09Z https://www.theskygallerypattaya.com/oai/oai.php

oai:theskygallerypattaya.com:10.29328/journal.hcem.1001002 2017-08-04 HCEM:VOL1

Effect on Vitamin D status of Breastfeeding Infants after Vitamin D3 Supplementation during Breastfeeding Lactation: A double-blind randomized controlled trial Sathit Niramitmahapanya Surasak Kaoiean Varaporn Sangtawesin Anusorn Patpanaprapan Narisa K BordeeratChaicharn Deerochanawong<h2>Abstract</h2><p><strong>Background:</strong> Vitamin D deficiency in pregnancy increases several risks of breastfed mothers. To prevent these adverse events, vitamin D supplementation during pregnancy and lactation is recommended, but suggested dose ranges vary.</p><p><strong>Objective:</strong> To determine whether vitamin D3 1,800 IU/d supplementation in lactating mothers improves the vitamin D status of their breastfed infants.</p><p><strong>Materials and Methods:</strong> A randomized, placebo&ndash;controlled trial with Thai pregnant women was conducted. Lactating mothers (n=72) and their breastfed infants with insufficient maternal 25 hydroxyvitamin D (25(OH)D) levels in the third trimester were randomly assigned to two groups, one of which received 1,800 IU/d vitamin D supplementation and the other a placebo. Maternal serum 25(OH)D during lactation, cord blood, and 6-week breastfed infant serum were measured using LC-MS/MS.</p><p><strong>Results: </strong>Mean maternal age (&plusmn;SD) was 27&plusmn;5 years, and pre-gestational BMI was 22.29&plusmn;5 kg/m2. Maternal serum 25(OH)D at baseline was 22.29&plusmn;7.15 nmol/L. At 6 weeks, both maternal 25(OH)D and infant 25 (OH)D levels had increased significantly in the vitamin D supplement group of mothers and infants (68.30&plusmn;15.40, 40.40&plusmn;12.56 nmol/L) compared to those in placebo groups (55.15&plusmn;13.57, 24.28&plusmn;17.20 nmol/L) (p &lt;0.001, p&lt;0.001). The changes in infant 25(OH)D levels increased substantially in the vitamin D supplement group but decreased in placebo(17.49&plusmn;16.27 ng/ml compared to -1.34&plusmn;19.23 nmol/L in the placebo group, p&lt;0.001). The change of maternal 25(OH)D were positively correlation to the change of 25(OH)D level in breastmilk mothers and infants by r=0.697, p&lt;0.001 and r=0.379, p=0.003 respectively.</p><p><strong>Conclusions: </strong>Vitamin D3 supplementation to breastfed mother during lactation can increase serum 25(OH)D level in Thai breastfed mother and infants. Further work is needed to determine the optimum duration of vitamin D supplementation to normalized breastfed infants with 25(OH)D level &gt;75 nmol/L.</p> Annals of Clinical Endocrinology and Metabolism - Heighten Science Publications Corporation 2017-08-04 Research Articlehttps://www.theskygallerypattaya.com/hcem/acem-aid1002.phpenCopyright © Sathit Niramitmahapanya et al.