2022-08-16T12:58:44Z https://www.theskygallerypattaya.com/oai/oai.php

oai:theskygallerypattaya.com:10.29328/journal.hcci.1001001 2017-11-14 HCCI:VOL1

Dendritic cells and TNF-Related apoptosis inducing ligand (TRAIL) represent new possibilities for sepsis treatment Petya Ganova Lyudmila Belenska-TodorovaNina Ivanovska<h2>Abstract</h2><p>Sepsis refers to a generalized inflammatory response of the organism to an infection or to bacterial products in circulation, rather than the development of an infection per se. Despite recent advances in clinical practice and overall medical care, sepsis remains a great health care problem and is still the most common cause of death in critically ill patients with infection. We suppose that during the course of sepsis the expression of TRAIL in different organs correlates with acute mortality and further development of multiple organ dysfunction syndrome (MODS). It is expected that dendritic cells (DCs) might become targets for apoptotic processes in a result of elevated TRAIL expression. This hypothesis is a bias for detailed investigations for in vivo studies in animal models and for in vitro studies of septic patients.</p> Insights in Clinical and Cellular Immunology - Heighten Science Publications Corporation 2017-11-14 Prospectivehttps://www.theskygallerypattaya.com/hcci/icci-aid1001.phpenCopyright © Petya Ganova et al.